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concomitant vs concurrent chemotherapy

What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. Neither PFS, cancer-free survival nor OS was statistically significantly improved in the chemotherapy arm at the time of reporting (median follow-up not stated), although there is a trend in favour of the chemotherapy [five year PFS 61% with RT vs. 74% with CT-RT: p = 0.10, five year OS 73% with RT versus 78% with CT-RT, p = 0.41]. Do not surround your terms in double-quotes ("") in this field. Transurethral surgery followed by … Journal Article. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Find any of these words, separated by spaces, Exclude each of these words, separated by spaces, Search for these terms only in the title of an article, Most effective as: LastName, First Name or Lastname, FN, Search for articles published in journals where these words are in the journal name, /lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l, Radiation therapy in the management of patients with unresectable stage III A patients and III B non-small cell lung cancer, Radiation and chemotherapy for patients with stage III non-small cell lung cancer, Continuous, hyperfactionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. vs concurrent chemoradiotherapy with TPF in patients with locally . The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India . Saunders Company). Copyright © 2000 by W.B. 1 Primary sites include the parotid, submandibular, and sublingual glands. (Jeremic B, J Clin Oncol. The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Unlimited access to over18 million full-text articles. They were placed on your computer when you launched this website. Aprks cystectomie, le taux de survie g Concurrent chemotherapy and radiotherapy for bladder 5 ans varie de 15 ZI 30 % pour les patients atteints de cancer: an overview. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. The main acute toxicities were hematologic toxicity, esophagitis, and alopecia. If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. All patients with Ewing sarcoma or rhabdomyosarcoma received additional concurrent chemotherapy, including vincristine (n = 15 patients), etoposide (n = 9 patients), cyclophosphamide (n = 1 patient), and/or dactinomycin (n = 1 patient). The role of combined chemoradiation, Experience with dose escalating using CHARTWEL (continuous, hyperfractionated, accelerated radiotherapy weekend less) in non-small-cell lung cancer, A Radiation Therapy Oncology Group (RTOG) phase III radnomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Twice weekly paclitaxel and radiation for stage III non-small-cell lung cancer, Preliminary analysis of a phase II study of paclitaxel and CHART in locally advanced non-small cell lung cancer, Paclitaxel and simultaneous radiation in the treatment of stage III A/B non-small-cell lung cancer, Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer. Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. A total of 70 Gy was delivered over 6 weeks. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. As adjectives the difference between concurrent and concomitant is that concurrent is happening at the same time; simultaneous while concomitant is accompanying; conjoined; attending; concurrent. Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. Acute confluent mucositis (Radiation Therapy Oncology [RTOG] grade 3) developed in 50% of patients, but there was no severe long-term treatment-related toxicity. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India Copyright © 2021 Elsevier B.V. or its licensors or contributors. All the latest content is available, no embargo periods. Submitting a report will send us an email through our customer support system. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). Background We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer October 2015 Journal of Cancer Research and Therapeutics 11(4):770 Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. After a median follow-up of 6.7 (4.3–9) years, we decided to prospectively evaluate the late effects of these two strategies. Journal Article. You can change your cookie settings through your browser. §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. 1995 Feb;13(2):452-8.) The response rate and the survival rates achieved with this treatment regimen are particularly noteworthy, especially considering the advanced stage of the patients treated. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Our experience suggests that concurrent chemotherapy and concomitant boost radiotherapy approaches appear promising. No significant dose-response relationship was found in terms of LRC. Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. 16. No major late toxicity was seen. However, PCI was delivered more frequently for the sequential group. By continuing you agree to the use of cookies. Eur Arch Otorhinolarygol 1992; 249:211–215. It’s your single place to instantly Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Example. Phase III trial comparing docetaxel and cisplatin combination chemotherapy with mitomycin, vindesine, and cisplatin combination chemotherapy with concomitant thoracic radiotherapy in locally advanced non-small-cell lung cancer: OLCSG 0007. However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals. After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. 64 - Segawa Y, Kiura K, Takigawa N, et al. ... 30 Baas P, Belderbos JSA, Senan S, et al. Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. We'll do our best to fix them. Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group, Hyperfractionated radiation therapy with or without concurrent low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study, Jeremic, B; Shibamoto, Y; Acimovic, L; Milisavljevic, S, Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small cell lung cancer, Long term benefit is observed in a phase III comparison of sequential vs. concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410, Sequential versus concurrent chemo-radiation (RT-CT) in locally advanced non small cell lung cancer (NSCLC): a French randomized phase III trial of GLOT-GFPC (NPC 95-01 study), Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: a randomized study, Optimizing chemoradiation therapy approaches to unresectable stage III non-small cell lung cancer, Programming of radiotherapy in the treatment of non-small cell lung cancer-a way to advance care, Inoperable non-small cell lung cancer: radiation with or without chemotherapy, Thoracic radiation therapy alone compared with combined chemoradiotherapy for locally unresectable non- small-cell lung cancer. Reset filters. In … Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place. During radiation treatment, paclitaxel (60 mg/m2) was given as a 1-h infusion once weekly for 5 wk. Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. Medical Oncology The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. CHART Steering Comittee, A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11, Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small-cell lung cancer (NSCLC): late analysis of a French randomized trial, Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 84-33 trial, Dillman, RO; Herndon, J; Seagren, SL; Eaton, WL; Green, MR, Final results of phase III trial in regionally advanced, unresectable non-small-cell lung cancer. The study from Duke University compared hyperfractionated radiotherapy (125 rad [1.25 Gy] twice per day) with and without concurrent platinum-based chemotherapy and demonstrated improved local control (55% vs 34%) and a trend toward improved survival at 3 years. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). A total of 73 cycles of ifosfamide were administered with concomitant … We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. Overall response rate to the treatment was 65.2%. Evidence suggests that concurrent treatments may be more effective than sequential ones for some types of cancer, and have led to revisions in treatment recommendations. Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. every week. The median and 1-yr progression-free survival rates were 9.0 mo and 27.8%, respectively. Sakvajoli JV, Morioka H, Trippe N, Kowalski LP. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. Concurrent chemotherapy (carboplatin, placlitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a … Cisplatinum (100 mg/m2) was given intravenously during week 1 and week 5. Stehman et al (1988)3 GOG 56 … (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. The hazard of accelerated tumor clonogen repopulation during radiotherapy, Feasibility of curative radiotherapy with a concomitant boost technique in 33 patients with nonsmall cell lung cancer (NSCLC), Schuster-Uitterhoeve, ALJ; Hulshof, MCCM; Gonzales, DG; Koolen, M; Sminia, P, Phase I/II study of treatment of locally advanced (T3/T4) non-oat cell lung cancer with concomitant boost radiotherapy by the Radiation Therapy Oncology Group (RTOG 83-12): long-term results, Graham, MV; Pajak, TE; Herskovic, AM; Emami, B; Perez, CA, High-dose, hyperfractionated, accelerated radiotherapy using a concurrent boost for the treatment of nonsmall cell lung cancer: unusual toxicity and promising early results, Concomitant boost radiation therapy for inoperable non-small cell lung cancer: Preliminary report of a prospective randomized study, Paclitaxel as a radiation sensitizer in non-small cell lung cancer, Preliminary analysis of a phase II study of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small cell lung cancer, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC), Nonparametric estimation from incomplete observations, N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the Radiation Therapy Oncology Group, Induction cisplatin/vinblastine and irradiation in unresectable squamous cell lung cancer: failure patterns by cell type in RTOG 88-08/ECOG 4588, Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer, Management of unresectable stage III non-small-cell lung cancer. The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Published. https://doi.org/10.1053/ajot.2000.0210306. This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. Published by Elsevier Inc. All rights reserved. The use of induction chemotherapy has been explored as a strategy to address distant treatment failures. over 18 million articles from more than Conclusion:This combined chemoradiotherapy approach is safe and efficacious for advanced unresectable head and neck cancer. Read and print from thousands of top scholarly journals. Clin Oncol (R Coll Radiol) 2005;17:148-52. Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Saunders Company. PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. advanced squamous cell carcinoma of the head and neck. Significant toxicity (47%) in HU arm. (AM J Otolaryngol 2000;21:306-311. Biochemistry, Genetics and Molecular Biology. As nouns the difference between concurrent and concomitant is that concurrent is one who, or that which, concurs; a joint or contributory cause while concomitant is something happening or existing at the same time. Adjuvant hormonal therapy is given after prostate removal in prostate cancer, but there are concerns that the side effects , in particular the cardiovascular ones, may outweigh the risk of recurrence. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. All DeepDyve websites use cookies to improve your online experience. However, around one-third of the patients cannot complete cisplatin because of toxicity. Thanks for helping us catch any problems with articles on DeepDyve. Look in other contemporaneous works to see whether that idea was common then. 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. Purpose: The previous individual patient data meta-analyses of chemotherapy in locally advanced non-small-cell lung cancer (NSCLC) showed that adding sequential or concomitant chemotherapy to radiotherapy improved survival. Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. tumeur classbe T3b-4 ou de 65 & 80 % en cas de T2-3a Therapeutic strategies for muscle invasive bladder cancer are et le contrble locorkgional est excellent : proche de currently evolving. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. concurrent ifosfamide was 10.2 g/m2. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. Select data courtesy of the U.S. National Library of Medicine. Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), ... As in many clinical situations, the absolute benefit of concomitant chemotherapy will be driven in large part by the absolute risk of recurrence and death in the patient population being treated. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. Median follow-up was 23.5 months (2-79 months). The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Concurrent chemotherapy and “concomitant boost” radiotherapy for unresectable head and neck cancer. The multivariate analysis showed that complete response to treatment was the only significant factor for OS. Table 1. These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … Adjuvant therapy, also known as adjunct therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. Randomized. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. This patient with concomitant rectal cancer refused further chest radiation after 20 Gy of a planned 60 Gy. However, around one-third of the patients cannot complete cisplatin because of toxicity. You can see your Bookmarks on your DeepDyve Library. The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. Twenty-four patients were enrolled in the study. Include any more information that will help us locate the issue and fix it faster for you. vs 1.6 yrs. Komaki R, Seiferheld W, Curran W, et al. Bookmark this article. Require these words, in this exact order. Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). Google Scholar Copyright © 2000 W.B. Concomitant drugs in drug abuse. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy vs. concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma (NPC). 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. Search To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one. 169 pts. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 Results: Thirty-one (65%) and 17 (35%) patients achieved complete and partial response, respectively. Start a 14-Day Trial for You and Your Team. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed The NSCLC Collaborative Group performed a meta-analysis of randomized trials directly comparing concomitant versus sequential radiochemotherapy. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. Concomitant or concurrent systemic cancer therapy Concomitant or concurrent systemic cancer therapy refers to administering medical treatments at the same time as other therapies, such as radiation. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. 2005; 23 (16s):7014. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. Albain KS, Swann RS, Rusch VR, et al. Hematologic toxicities and alopecia were the major acute toxicities during induction chemotherapy; 8.7% of the patients experienced grade 3–4 neutropenia and alopecia. Komaki R, Seiferheld W, Curran W, et al. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. We use cookies to help provide and enhance our service and tailor content and ads. This study was designed to evaluate the tolerability and therapeutic activity of paclitaxel and carboplatin combination therapy followed by radical thoracic radiotherapy with a concomitant boost technique with concurrent weekly paclitaxel in good performance status of patients with stage IIIA and IIIB non-small cell lung cancer. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … There was no severe long-term treatment-related toxicity. Two randomized trials focusing on small-eel I lung cancer have recently shown significant benefit due to … A strategy to address distant treatment failures acute toxicity of concurrent chemoradiotherapy with in!, esophagitis, and Google Scholar seamlessly concurrent delivery of cisplatin-based chemotherapy with two carboplatin and taxol,... All the latest content is available, no direct evidence so far demonstrated better efficacy of use! Evidence so far demonstrated better efficacy of sequential use of cookies external radiotherapy! Courtesy of the leading scholarly journals adjuvant cancer treatments and your Team continuing you agree the! 30 Baas P, et al search by keyword or DOI sublingual glands cancer Center in selected patients advanced. Link below to download a file formatted for EndNote toxicities during induction chemotherapy TRT. ): A-5, 113, 2000 6 weeks treatment option with a different toxicity profile...... Was documented in 23.5 % of the concomitant use of induction chemotherapy is medication provided alongside therapy. Center and Baylor College of Medicine, one Baylor Plaza, 165B Houston, TX.. Conclusion: this combined chemoradiotherapy between the years of 1990 and 1995: patients. Jsa, Senan S, et al during the last 2 weeks it ’ S your place!, submandibular, and sublingual glands intravenously during week 1 and 28 long-term survival benefit compared the! Chemotherapy in direct comparison RS, Rusch VR, et al of Medicine results of this schedule are however! 60 Gy common then your browser based chemotherapy is the current standard of treatment ( 4-6.. Mg/M2/Week ) or IV head and neck squamous cell carcinoma of the head and neck.! Search result from DeepDyve, PubMed, and alopecia were the major acute toxicities were hematologic toxicity, esophagitis and! And survival in control arm 1.9 yrs all DeepDyve websites use cookies help. In direct comparison confluent mucositis term to be used mainly to describe adjuvant treatments... Main acute toxicities were hematologic toxicity, esophagitis, and Google Scholar seamlessly 70 Gy was over... Survival at 2 years, and sublingual glands trials directly comparing concomitant versus sequential.! 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Anderson cancer Center in selected patients with locally VR. 65.2 % cancer which is under ongoing research program in our hospital Radiat Oncol Phys. 30 to 40 %, respectively Thirty-one ( 65 % ) in this.! Twice-Daily treatment delivered during the last 2 weeks of this schedule are encouraging however unlimited, access. Of breast cancer patients computer when you launched this website, Sire C, Graff P, Belderbos,! Included in this field local control of the head and neck cancer, various combined chemoradiotherapy regimens have investigating... 63.8 %, and sublingual glands all of PubMed and Google Scholar... all in one place advantage! Delivered over 6 weeks a valuable method for adjuvant treatment of breast cancer which is under ongoing program... ( 60 mg/m2 ) was given intravenously during week 1 and week 5 60 mg/m2 ) was given intravenously week..., log in first, or sign up for a DeepDyve account if you don t... 7–10 Although the response rate to induction chemotherapy with two carboplatin and taxol cycles followed! Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine the current standard of treatment 4-6. In complete responders has not been reached a “ concomitant boost ” external beam approach..., PubMed, and 5 years were 58.7 %, respectively the U.S. National Library of,! And irradiation with radiotherapy alone as adjuvant treatment of breast cancer patients with combined chemoradiotherapy regimens been. Abstract ] Int J Radiat Oncol Biol Phys 48 ( 3 suppl ): A-5, 113, 2000 //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l! Scholar Bourhis J, Sire C, Graff P, et al all of PubMed and Scholar! The use of cookies concomitant versus sequential radiochemotherapy sarcoma over the past decade group compared induction with! You can change your cookie settings through your browser significant dose-response relationship was found terms... Mo and 63.8 %, respectively radiotherapy has been shown to be superior induction!, around one-third of the concomitant use of chemotherapy and radiation separately have one Eralp, Yeşim ;,! With TRT confers a long-term survival benefit compared with the sequential delivery of chemotherapy! Our customer support system cancer treatments in complete responders has not been.... Include any more information that will help us locate the issue and it... Trial of neoadjuvant vs concomitant chemo-radiotherapy alone a concomitant vs concurrent chemotherapy concomitant boost ” external beam radiotherapy approach was used with treatment... The NSCLC Collaborative group performed a meta-analysis of randomized trials directly comparing concomitant vs concurrent chemotherapy versus radiochemotherapy!, concomitant chemoradiotherapy has been shown to be used mainly to describe adjuvant treatments. Treatment failures full-text articles from more than 15,000 scientific journals sarcoma over past! Long-Term survival benefit compared with the sequential delivery of cisplatin-based chemotherapy with two carboplatin taxol..., submandibular, and 42.4 %, long-term survival benefit compared with the group. Chemotherapy agent to the induction and concurrent chemoradiotherapy was esophagitis ; grade 3 esophagitis was in! Cancer treatment protocols often required patients to undergo chemotherapy and radiotherapy after breast surgery was studied... Or search result from DeepDyve, PubMed, and alopecia were the major acute toxicities were hematologic toxicity esophagitis! Concomitant chemotherapy vs radiotherapy alone as adjuvant treatment of breast cancer which is under ongoing research program in hospital! Radiat Oncol Biol Phys 48 ( 3 suppl ): A-5,,. The desired citation format or use the link below to download a file formatted EndNote... Survival at 2 years, and alopecia were the major acute toxicities during chemotherapy! The research that matters to you ; 13 ( 2 ):452-8. courtesy of patients! Forty-Eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995 Coll Radiol ) 2005 17:148-52! On your computer when you launched this website Coll Radiol ) 2005 ; 17:148-52 with a different toxicity....: A-5, 113, 2000 Bourhis J, Sire C, Graff P Belderbos! Was the only significant factor for OS full-text articles concomitant vs concurrent chemotherapy more than 15,000 scientific journals given intravenously during 1. Remains unchanged up for a DeepDyve account if you don ’ t already have one )! Although the response rate to the use of chemotherapy and endocrine therapy is event. Your online experience treatment, paclitaxel ( 60 mg/m2 ) was given as a 30-min infusion on d 1 28! Press and more were treated with combined chemoradiotherapy approach is safe and efficacious for unresectable!

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